ʻAʻohe lāʻau lapaʻau no ka maʻi o Alzheimer, akā ke ʻimi mau nei nā kānaka ʻepekema i nā ala e mālama ai i nā hōʻailona o ka maʻi.
Ke hana pū nei nā kānaka noiʻi i ka ʻike mua ʻana i ka dementia e pili ana i ka maʻi Alzheimer, ʻoiai hiki i ka ʻike mua ʻana ke kōkua i ka mālama ʻana.
Hiki i ka waikawa formic i loko o ka mimi ke lilo i biomarker kūpono no ka ʻike mua ʻana i ka maʻi Alzheimer, e like me kahi noiʻi hou i paʻi ʻia ma Frontiers in Aging Neuroscience.
Ua wehewehe ka US Centers for Disease Control and Prevention (CDC) i ka dementia ma ke ʻano he "hōʻino i ka hoʻomanaʻo, ka noʻonoʻo ʻana, a i ʻole ka hoʻoholo ʻana e hoʻopilikia ai i nā hana o kēlā me kēia lā."
Ma waho aʻe o ka maʻi Alzheimer, aia kekahi mau ʻano dementia e like me ka dementia me nā kino Lewy a me ka dementia vascular. Akā ʻo Alzheimer ke ʻano maʻamau o ka dementia.
Wahi a ka hōʻike a ka Alzheimer's Disease Association no 2022, ma kahi o 6.5 miliona mau kānaka ma ʻAmelika Hui Pū ʻIa e noho nei me ka maʻi. Eia kekahi, manaʻo nā kānaka noiʻi e pāpālua kēlā helu i ka makahiki 2050.
Eia kekahi, ʻo ka poʻe me ka maʻi Alzheimer holomua e paʻakikī paha i ka ale ʻana, ka ʻōlelo ʻana, a me ka hele ʻana.
A hiki i ka hoʻomaka ʻana o nā makahiki 2000, ʻo ka autopsy wale nō ke ala e hōʻoia ai inā he maʻi Alzheimer a kekahi kanaka a i ʻole kekahi ʻano dementia ʻē aʻe.
Wahi a ka National Institute on Aging, hiki i nā kauka ke hana i kahi lumbar puncture, i ʻike ʻia hoʻi he lumbar puncture, e nānā i nā biomarkers e pili ana i ka maʻi Alzheimer.
Huli nā kauka i nā biomarkers e like me ka beta-amyloid 42, ka mea nui o nā plaques amyloid i loko o ka lolo, a e nānā paha i nā mea ʻē ma kahi PET scan.
"ʻO nā ʻano hana kiʻi hou, ʻo ia hoʻi ke kiʻi amyloid, ka amyloid PET imaging, a me ka tau PET imaging, e ʻae iā mākou e ʻike i nā ʻano ʻē i loko o ka lolo i ka wā e ola ana ke kanaka," wahi a ke polopeka olakino a me ke kauka ʻo Kenneth M. Dr. Langa ma Ann Arbor, ka mea i komo ʻole i ka noiʻi, i ʻōlelo ma kahi podcast Michigan Medicine hou.
Hiki i kekahi mau koho lapaʻau ke kōkua i ka hōʻemi ʻana i ka koʻikoʻi o nā hōʻailona hānō a hoʻolohi i ka holomua o ka maʻi, ʻoiai ʻaʻole hiki iā lākou ke ho'ōla.
Eia kekahi laʻana, hiki i ke kauka ke kuhikuhi i nā lāʻau lapaʻau e like me ka donepezil a i ʻole galantamine e hōʻemi i nā hōʻailona hānō. Hiki i kahi lāʻau noiʻi i kapa ʻia ʻo lecanemab ke hoʻolohi i ka holomua o ka maʻi Alzheimer.
Ma muli o ke kumukūʻai o ka hoʻāʻo ʻana no ka maʻi Alzheimer a ʻaʻole paha e loaʻa i nā mea āpau, ke hoʻoikaika nei kekahi poʻe noiʻi i ka nānā mua ʻana.
Ua kālailai pū nā kānaka noiʻi mai ke Kulanui ʻo Shanghai Jiaotong a me ka WuXi Institute of Diagnostic Innovation o Kina i ke kuleana o ka waikawa formic ma ke ʻano he biomarker o ka maʻi Alzheimer i loko o ka mimi.
Ua koho nā kānaka ʻepekema i kēia hui kūikawā ma muli o nā haʻawina biomarker maʻi Alzheimer ma mua. Hoʻomaopopo lākou ʻo ka metabolism formaldehyde maʻamau kahi hiʻohiʻona koʻikoʻi o ka hemahema o ka noʻonoʻo e pili ana i ka makahiki.
No kēia haʻawina, ua hoʻopaʻa inoa nā mea kākau i 574 mau mea komo mai ka Memory Clinic o ka Halemai ʻEono o nā Kānaka o Shanghai, Kina.
Ua māhele lākou i nā mea komo i ʻelima mau pūʻulu e pili ana i kā lākou hana ʻana i nā hoʻokolohua o ka hana cognitive; ua like kēia mau hui mai ka noʻonoʻo olakino a hiki i ka maʻi Alzheimer:
Ua hōʻiliʻili nā kānaka noiʻi i nā laʻana mimi mai nā mea komo no nā pae waikawa formic a me nā laʻana koko no ka nānā ʻana i ka DNA.
Ma ka hoʻohālikelike ʻana i nā pae waikawa formic i kēlā me kēia hui, ua ʻike nā mea noiʻi i nā ʻokoʻa ma waena o nā poʻe komo olakino cognitive a me ka poʻe me ka liʻiliʻi o kekahi kekelē o ka hemahema cognitive.
I loko o nā hui me kekahi kekelē o ka emi ʻana o ka ʻike, ʻoi aku ke kiʻekiʻe o ka waikawa formic i loko o ka mimi ma mua o nā hui me nā hana ʻike olakino.
Eia kekahi, ʻoi aku ka nui o nā pae o ka waikawa formic i loko o ka mimi o ka poʻe i loaʻa i ka maʻi Alzheimer ma mua o ka poʻe i loaʻa i ke olakino noʻonoʻo.
Ua ʻike pū nā kānaka ʻepekema i kahi pilina maikaʻi ʻole ma waena o ka pae o ka waikawa formic i loko o ka mimi a me nā hoʻokolohua cognitive ma nā wahi o ka hoʻomanaʻo a me ka nānā.
"Ua hoʻokiʻekiʻe nui ʻia ka UA i loko o ka hui hōʻailona [subjective cognitive decline], ʻo ia hoʻi, hiki ke hoʻohana ʻia ka UA no ka hōʻailona mua [o ka maʻi Alzheimer]," kākau nā mea kākau.
He mea nui nā hopena o kēia noiʻi no kekahi mau kumu, ʻaʻole ka mea liʻiliʻi ke kumukūʻai kiʻekiʻe o ka ʻike ʻana i ka maʻi Alzheimer.
Inā hōʻike hou aku nā noiʻi hiki i ka mimi formate ke ʻike i ka emi ʻana o ka noʻonoʻo, hiki i kēia ke lilo i mea maʻalahi e hoʻohana a kūpono hoʻi.
Eia kekahi, inā hiki i kēlā hoʻokolohua ke ʻike i ka emi ʻana o ka noʻonoʻo e pili ana i ka maʻi Alzheimer, hiki i nā loea olakino ke komo koke.
Ua haʻi aku ʻo Kauka Sandra Petersen, DNP, ka hope pelekikena kiʻekiʻe o ke olakino a me ka pono ma Pegasus Senior Living, iā Medical News Today e pili ana i ke aʻo ʻana:
"Hoʻomaka nā loli i ka maʻi Alzheimer ma kahi o 20 a 30 mau makahiki ma mua o ka hōʻoia ʻana a ʻike pinepine ʻole ʻia a hiki i ka wā e ulu ai ka pōʻino koʻikoʻi. Ua ʻike mākou hiki i ka ʻike mua ʻana ke alakaʻi i nā koho lapaʻau hou aʻe no nā maʻi a me ka hiki ke hoʻolālā no ka mālama ʻana i ka wā e hiki mai ana."
"ʻO kahi holomua i kēlā ʻano hoʻāʻo (ʻaʻole invasive a me ke kumu kūʻai ʻole) i loaʻa i ka lehulehu, he mea hoʻololi pāʻani ia i ke kaua ʻana i ka maʻi Alzheimer," wahi a Kauka Peterson.
Ua ʻike koke aku nei nā kānaka ʻepekema i kahi biomarker e hiki ke kōkua i nā kauka e ʻike mua i ka maʻi o Alzheimer. E ʻae kēia i nā kauka…
ʻO nā mea hou i loaʻa i nā ʻiole i kekahi lā e kōkua i ka hana ʻana i kahi hoʻāʻo koko e lilo i ʻāpana o ka nānā ʻana no Alzheimer a me nā ʻano ʻē aʻe o…
Hoʻohana kahi noiʻi hou i nā scan lolo PET e wānana i ka emi ʻana o ka cognitive ma muli o ke alo o nā protein amyloid a me tau i loko o ka lolo, ma waena o nā mea ʻē aʻe cognitive…
Ke hoʻohana nei nā kauka i nā hoʻokolohua cognitive like ʻole a me nā scans e ʻike ai i ka maʻi Alzheimer. Ua hoʻomohala nā kānaka noiʻi i kahi algorithm hiki ke hoʻohana ʻia ma kekahi…
ʻO ka hoʻokolokolo maka wikiwiki paha e hāʻawi i ka ʻike koʻikoʻi e pili ana i ke olakino o ka lolo i kekahi lā. Ma ke ʻano kūikawā, hiki iā ia ke ʻike i nā hōʻailona o ka dementia.