Ua hōʻike nā hopena o kahi noiʻi a kahi hui mai ke Kulanui ʻo Shanghai Jiaotong he biomarker mimi koʻikoʻi ka waikawa formic e hiki ke ʻike i ka maʻi Alzheimer (AD) mua. Hiki i nā ʻike ke hoʻomākaukau i ke ala no ka nānā nui ʻana me ke kumu kūʻai haʻahaʻa a maʻalahi hoʻi. Ua paʻi ʻo Kauka Yifan Wang, Kauka Qihao Guo a me nā hoa hana i kahi ʻatikala i kapa ʻia ʻo "Systematic Evaluation of Formic Acid in Urine as a New Potential Alzheimer's Biomarker" ma Frontiers in Aging Neuroscience. Ma kā lākou ʻōlelo, ua hoʻoholo nā mea kākau: "He maikaʻi loa ka waikawa Formic i loko o ka mimi no ka nānā mua ʻana no ka maʻi Alzheimer ... He kūpono a hoʻokele waiwai ka ʻike ʻana i nā biomarkers o ka maʻi Alzheimer i loko o ka mimi. Pono e hoʻokomo ʻia i loko o ka hoʻokolokolo lapaʻau maʻamau o ka poʻe ʻelemakule."
Ua wehewehe nā mea kākau ʻo AD, ke ʻano maʻamau o ka dementia, ua hōʻailona ʻia e ka holomua o ka noʻonoʻo a me ka hana. ʻO nā hiʻohiʻona pathological nui o AD e komo pū ana me ka hōʻiliʻili maʻamau ʻole o ka extracellular amyloid β (Aβ), ka hōʻiliʻili maʻamau ʻole o nā neurofibrillary tau tangles, a me ka hōʻino synapse. Eia naʻe, ua hoʻomau ka hui, "ʻaʻole i maopopo loa ka pathogenesis o AD."
Hiki ke ʻike ʻole ʻia ka maʻi Alzheimer a hiki i ka wā lohi no ka mālama ʻana. "He maʻi mau loa a hoʻopunipuni hoʻi ia, ʻo ia hoʻi hiki ke ulu a hoʻomau no nā makahiki he nui ma mua o ka ʻike ʻia ʻana o ka hemahema o ka noʻonoʻo," wahi a nā mea kākau. "Hana ʻia nā pae mua o ka maʻi ma mua o ke kahua o ka dementia hiki ʻole ke hoʻihoʻi ʻia, ʻo ia ka puka makani gula no ke komo ʻana a me ka mālama ʻana. No laila, pono ka nānā nui ʻana no ka maʻi Alzheimer mua i ka poʻe ʻelemakule."
ʻOiai ke kōkua nei nā papahana loiloi lehulehu i ka ʻike ʻana i ka maʻi i ka wā mua, ʻoi aku ka paʻakikī a me ke kumukūʻai o nā ʻano hana diagnostic o kēia manawa no ka nānā maʻamau. Hiki i ka Positron emission tomography-computed tomography (PET-CET) ke ʻike i nā waihona Aβ mua, akā he pipiʻi a hōʻike i nā mea maʻi i ka radiation, ʻoiai nā hoʻokolohua biomarker e kōkua i ka ʻike ʻana iā Alzheimer e koi ana i nā huki koko invasive a i ʻole nā ​​​​​​punctures lumbar e loaʻa ai ka wai cerebrospinal, kahi mea hoʻopailua paha i nā mea maʻi.
Ua ʻike nā kānaka noiʻi ua hōʻike kekahi mau noiʻi he hiki ke nānā i nā maʻi no nā biomarkers urinary o AD. ʻAʻole komo ka urinalysis a he kūpono hoʻi, e kūpono ana no ka nānā nui ʻana. Akā, ʻoiai ua ʻike mua nā kānaka ʻepekema i nā biomarkers urinary no AD, ʻaʻohe mea kūpono no ka ʻike ʻana i nā pae mua o ka maʻi, ʻo ia hoʻi, ʻaʻohe puka makani gula no ka mālama mua ʻana.
Ua aʻo mua ʻo Wang a me nā hoa hana i ka formaldehyde ma ke ʻano he biomarker urinary no ka maʻi Alzheimer. "I nā makahiki i hala iho nei, ua ʻike ʻia ka metabolism formaldehyde maʻamau ʻole ʻo ia kekahi o nā hiʻohiʻona nui o ka hemahema cognitive e pili ana i ka makahiki," wahi a lākou. "Ua hōʻike kā mākou noiʻi mua i kahi pilina ma waena o nā pae formaldehyde urinary a me ka hana cognitive, e hōʻike ana he biomarker hiki ke loaʻa ka formaldehyde urinary no ka ʻike mua ʻana o AD."
Eia nō naʻe, aia kahi no ka hoʻomaikaʻi ʻana i ka hoʻohana ʻana i ka formaldehyde ma ke ʻano he biomarker no ka ʻike mua ʻana i nā maʻi. I kā lākou noiʻi i paʻi ʻia nei, ua kālele ka hui ma ka formate, kahi metabolite formaldehyde, e ʻike inā hana maikaʻi ia ma ke ʻano he biomarker.
Ua komo pū ka hui noiʻi me 574 mau kānaka, me nā maʻi me ka maʻi Alzheimer o nā ʻano koʻikoʻi like ʻole, a me nā mea komo olakino maʻamau. Ua kālailai nā mea noiʻi i nā laʻana mimi a me ke koko mai nā mea komo e ʻimi i nā ʻokoʻa i nā biomarkers mimi a ua hana i kahi loiloi psychological. Ua māhele ʻia nā mea komo i ʻelima mau pūʻulu e pili ana i kā lākou mau maʻi: maʻamau cognitive (NC) 71 mau kānaka, emi ʻana o ka cognitive subjective (SCD) 101, ʻaʻohe hemahema cognitive iki (CINM), hemahema cognitive 131, hemahema cognitive iki (MCI) 158 mau kānaka, a me 113 me BA. .
Ua ʻike ʻia ma ke aʻo ʻana ua kiʻekiʻe nui nā pae waikawa formic urinary i nā hui maʻi Alzheimer āpau a ua pili pū me ka emi ʻana o ka noʻonoʻo i hoʻohālikelike ʻia me nā kaohi olakino, me ka hui emi ʻana o ka noʻonoʻo mua. Hōʻike kēia e hiki i ka waikawa formic ke lawelawe ma ke ʻano he biomarker koʻikoʻi no ke kahua mua o AD. "Ma kēia haʻawina, hōʻike mākou no ka manawa mua e loli ana nā pae waikawa formic urinary me ka emi ʻana o ka noʻonoʻo," wahi a lākou. "Ua hōʻike ka waikawa formic urinary i ka pono kūikawā i ka ʻike ʻana iā AD. Eia kekahi, ua hoʻonui nui ʻia ka waikawa formic urinary i ka hui ʻike SCD, ʻo ia hoʻi hiki ke hoʻohana ʻia ka waikawa formic urinary no ka ʻike mua ʻana iā AD."
ʻO ka mea hoihoi, i ka wā i kālailai ai nā kānaka noiʻi i nā pae formate o ka mimi i hui pū ʻia me nā biomarkers koko o Alzheimer, ua ʻike lākou hiki iā lākou ke wānana pololei i ke kahua o ka maʻi i nā maʻi. Eia nō naʻe, pono ka noiʻi hou aku e hoʻomaopopo i ka pilina ma waena o ka maʻi Alzheimer a me ka waikawa formic.
Eia nō naʻe, ua hoʻoholo nā mea kākau: "ʻAʻole hiki ke hoʻohana wale ʻia nā pae formate mimi a me ka formaldehyde e hoʻokaʻawale iā AD mai NC, akā hoʻomaikaʻi pū i ka pololei o ka wānana ʻana o nā biomarkers plasma no ke kahua maʻi AD. nā biomarkers hiki ke loaʻa no ka ʻike ʻana".