Ua loiloi ʻia kēia ʻatikala e like me nā kaʻina hana hoʻoponopono a me nā kulekele o Science X. Ua hoʻokūpaʻa nā mea hoʻoponopono i kēia mau ʻano maikaʻi me ka hōʻoia ʻana i ka pono o ka ʻike:
ʻO ka papa waho pipili o nā fungi a me nā bacteria, i kapa ʻia ʻo "extracellular matrix" a i ʻole ECM, he ʻano like me ka jelly a hana ma ke ʻano he papa pale a me ka pūpū. Akā e like me kahi noiʻi hou i paʻi ʻia ma ka puke pai ʻo iScience, i mālama ʻia e ke Kulanui o Massachusetts Amherst ma ka laulima ʻana me Worcester Polytechnic Institute, ʻo ka ECM o kekahi mau microorganism e hana i kahi gel wale nō i ke alo o ka waikawa oxalic a i ʻole nā ​​​​waikawa maʻalahi ʻē aʻe. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2′); });
Ma muli o ke kuleana koʻikoʻi o ka ECM i nā mea āpau mai ke kū'ē ʻana i nā antibiotic a hiki i nā paipu i paʻa a me ka haumia o nā mea lapaʻau, ʻo ka hoʻomaopopo ʻana i ke ʻano o ka hoʻoponopono ʻana o nā microorganism i kā lākou mau papa gel sticky he hopena ākea ia no ko mākou ola o kēlā me kēia lā.
"Ua hoihoi mau wau i nā microbial ECMs," wahi a Barry Goodell, polopeka o ka microbiology ma ke Kulanui o Massachusetts Amherst a me ka mea kākau kiʻekiʻe o ka pepa. "Manaʻo pinepine ka poʻe i ka ECM ma ke ʻano he papa pale waho inert e pale ana i nā microorganisms. Akā hiki iā ia ke hana ma ke ʻano he ala e ʻae ai i nā meaʻai a me nā enzymes e neʻe i loko a i waho o nā cell microbial."
He nui nā hana a ka uhi ʻana: ʻo kona ʻano pipili, ʻo ia hoʻi, hiki i nā microorganism pākahi ke hui pū e hana i nā kolone a i ʻole "biofilms", a inā lawa nā microorganism e hana i kēia, hiki iā ia ke pani i nā paipu a hoʻohaumia paha i nā lako lapaʻau.
Akā, pono nō hoʻi e permeable ka pūpū. Hoʻopuka ka nui o nā microorganisms i nā enzymes like ʻole a me nā metabolites ʻē aʻe ma o ka ECM i loko o nā mea a lākou e makemake ai e ʻai a hoʻopili paha (e like me ka lāʻau pala a i ʻole nā ​​​​ʻiʻo vertebrate), a laila, ke hoʻopau nā enzymes i kā lākou hana digestive, hoʻoneʻe i nā meaʻai ma o ka ECM. hoʻihoʻi ʻia ka hui i loko o ke kino. matrix extracellular.
ʻO ke ʻano o kēia, ʻaʻole wale ka ECM he papa pale inert; ʻOiaʻiʻo, e like me ka hōʻike ʻana a Goodell a me nā hoa hana, ʻike ʻia he hiki i nā microorganism ke kāohi i ka stickiness o kā lākou ECM a no laila ko lākou permeability. Pehea lākou e hana ai? Kiʻi kiʻi: B. Goodell
I loko o nā halo, ʻike ʻia ka mea i hoʻokuʻu ʻia he waikawa oxalic, kahi waikawa organik maʻamau i loaʻa maoli i nā mea kanu he nui. E like me ka ʻike ʻana o Goodell a me kāna mau hoa hana, ʻike ʻia he nui nā microbes e hoʻohana i ka waikawa oxalic a lākou e hoʻokuʻu ai e hoʻopaʻa i ka papa waho o nā kalapona, e hana ana i kahi ECM pipili, e like me ka gel.
Akā i ka nānā pono ʻana o ka hui, ua ʻike lākou ʻaʻole i kōkua wale ka waikawa oxalic i ka hana ʻana i ka ECM, akā ua "hoʻoponopono" pū kekahi iā ia: ʻo ka nui o ka waikawa oxalic i hoʻohui ʻia e nā microbes i ka hui ʻana o ka carbohydrate-acid, ʻoi aku ka mānoanoa o ka ECM. ʻO ka nui o ka mānoanoa o ka ECM, ʻoi aku ka ālai ʻana i nā molekala nui mai ke komo ʻana a i ʻole ka haʻalele ʻana i ka microbe, ʻoiai nā molekala liʻiliʻi e noho manuahi ana e komo i ka microbe mai ke kaiapuni a me ka ʻaoʻao ʻē aʻe.
Hoʻokūkū kēia ʻike i ka ʻike ʻepekema kuʻuna o ke ʻano o ka hele ʻana o nā ʻano hui like ʻole i hoʻokuʻu ʻia e nā fungi a me nā bacteria mai kēia mau microorganism i ke kaiapuni. Ua hōʻike ʻo Goodell a me nā hoa hana i kekahi mau hihia, pono paha nā microorganism e hilinaʻi hou aku i ka hoʻokuʻu ʻia ʻana o nā mole liʻiliʻi loa e hoʻouka i ka matrix a i ʻole ka ʻiʻo e hilinaʻi ai ka microorganism e ola a i ʻole e loaʻa i ka maʻi.
ʻO ke ʻano kēia, hiki i ka hoʻokuʻu ʻia ʻana o nā molekala liʻiliʻi ke pāʻani i kahi kuleana nui i ka pathogenesis inā ʻaʻole hiki i nā enzymes nui ke hele ma o ka matrix extracellular microbial.
"Me he mea lā he kahua waena," wahi a Goodell, "kahi e hiki ai i nā microorganism ke hoʻomalu i nā pae acidity e hoʻololi i kahi ʻano kikoʻī, e mālama ana i kekahi o nā molekala nui, e like me nā enzymes, ʻoiai e ʻae ana i nā molekala liʻiliʻi e hele maʻalahi ma o ka ECM."
ʻO ka hoʻololi ʻana o ka ECM e ka waikawa oxalic paha ke ala no nā microorganism e pale aku iā lākou iho mai nā antimicrobials a me nā antibiotics, ʻoiai he nui o kēia mau lāʻau i hana ʻia me nā molekala nui loa. ʻO kēia hiki ke hoʻopilikino ʻia e lilo i kī i ka lanakila ʻana i kekahi o nā pilikia nui i ka lāʻau antimicrobial, ʻoiai ʻo ka hoʻopunipuni ʻana i ka ECM e ʻoi aku ka permeable e hiki ke hoʻomaikaʻi i ka pono o nā antibiotics a me nā antimicrobials.
"Inā hiki iā mākou ke kāohi i ka biosynthesis a me ka hoʻokuʻu ʻana o nā waikawa liʻiliʻi e like me ka oxalate i loko o kekahi mau microbes, hiki iā mākou ke kāohi i nā mea e komo i loko o nā microbes, kahi e hiki ai iā mākou ke mālama maikaʻi i nā maʻi microbial he nui," wahi a Goodell.
ʻIke hou aku: Gabriel Perez-Gonzalez et al., Ka launa pū ʻana o nā oxalates me ka beta-glucan: nā hopena no ka matrix extracellular fungal a me ka lawe ʻana o ka metabolite, iScience (2023). DOI: 10.1016/j.isci.2023.106851
Inā loaʻa iā ʻoe kahi typo, hewa, a i ʻole makemake ʻoe e waiho i kahi noi e hoʻoponopono i ka ʻike ma kēia ʻaoʻao, e ʻoluʻolu e hoʻohana i kēia palapala. No nā nīnau maʻamau, e ʻoluʻolu e hoʻohana i kā mākou palapala hoʻokaʻaʻike. No ka manaʻo maʻamau, e hoʻohana i ka ʻāpana manaʻo lehulehu ma lalo (e hahai i nā kuhikuhi).
He mea nui loa kāu manaʻo iā mākou. Eia nō naʻe, ma muli o ka nui o nā leka, ʻaʻole hiki iā mākou ke hōʻoia i kahi pane pilikino.
Hoʻohana wale ʻia kāu leka uila e haʻi i ka poʻe i hoʻouna mai i ka leka uila. ʻAʻole e hoʻohana ʻia kou helu wahi a me ka helu wahi o ka mea loaʻa no kekahi kumu ʻē aʻe. E ʻike ʻia ka ʻike āu e hoʻokomo ai i kāu leka uila a ʻaʻole e mālama ʻia e Phys.org ma kekahi ʻano.
E loaʻa i nā mea hou i kēlā me kēia pule a/a i ʻole i kēlā me kēia lā ma kāu pahu leka. Hiki iā ʻoe ke kāpae i kāu kau inoa i kēlā me kēia manawa a ʻaʻole loa mākou e kaʻana like i kāu ʻike me nā ʻaoʻao ʻekolu.
Hoʻolako mākou i kā mākou ʻike i nā mea āpau. E noʻonoʻo e kākoʻo i ka misionari a Science X me kahi moʻokāki premium.
Hoʻohana kēia pūnaewele i nā kuki e hoʻomaʻalahi i ka hoʻokele ʻana, kālailai i kāu hoʻohana ʻana i kā mākou lawelawe, hōʻiliʻili i ka ʻikepili pilikino hoʻolaha, a hāʻawi i ka ʻike mai nā ʻaoʻao ʻekolu. Ma ka hoʻohana ʻana i kā mākou pūnaewele, ke ʻae nei ʻoe ua heluhelu a hoʻomaopopo ʻoe i kā mākou Kulekele pilikino a me nā ʻŌlelo Hoʻohana.