Hoʻohana mākou i nā kuki e hoʻomaikaʻi i kou ʻike. Ma ka hoʻomau ʻana e nānā i kēia pūnaewele, ʻae ʻoe i kā mākou hoʻohana ʻana i nā kuki. ʻIke hou aku.
Ma ke kaomi ʻana iā "ʻAe i nā mea āpau", ʻae ʻoe i ka mālama ʻana i nā kuki ma kāu hāmeʻa e hoʻomaikaʻi i ka hoʻokele pūnaewele, kālailai i ka hoʻohana ʻana i ka pūnaewele, a kākoʻo i kā mākou hāʻawi ʻana i nā ʻike ʻepekema manuahi a wehe ʻia. ʻIke hou aku.
Hiki i kahi hoʻāʻo mimi maʻalahi ke ʻike i ka maʻi Alzheimer i ke kahua mua, e hoʻomākaukau ana i ke ala no nā papahana nānā nui? Hōʻike maoli ka haʻawina Frontiers in Aging Neuroscience hou i kēia. Ua hoʻāʻo nā mea noiʻi i kahi hui nui o nā maʻi Alzheimer o nā ʻano koʻikoʻi like ʻole a me nā poʻe olakino i maʻamau ka noʻonoʻo e ʻike i nā ʻokoʻa i nā biomarkers mimi.
Ua ʻike lākou he hōʻailona koʻikoʻi ka waikawa formic i loko o ka mimi o ka emi ʻana o ka noʻonoʻo pilikino a hiki ke hōʻike i nā pae mua o ka maʻi Alzheimer. ʻO nā ʻano hana e kū nei no ka ʻike ʻana i ka maʻi Alzheimer he pipiʻi, he mea pono ʻole, a ʻaʻole hiki ke hoʻohana ʻia no ka nānā maʻamau. ʻO ke ʻano kēia, ʻike ʻia ka hapa nui o nā maʻi i ka wā e lohi ai no ka mālama pono ʻana. Eia nō naʻe, ʻo ka urinalysis non-invasive, pipiʻi, a maʻalahi hoʻi no ka waikawa formic paha ka mea a nā kauka e noi nei no ka nānā mua ʻana.
"He maʻi mau a hoʻopunipuni ka maʻi Alzheimer, ʻo ia hoʻi hiki ke ulu a hoʻomau no nā makahiki he nui ma mua o ka ʻike ʻia ʻana o ka hemahema o ka noʻonoʻo," wahi a nā mea kākau. "Hōʻike ʻia nā pae mua o ka maʻi ma mua o ke kahua o ka dementia hiki ʻole ke hoʻihoʻi ʻia, ʻo ia ka puka makani gula no ke komo ʻana a me ka mālama ʻana. No laila, pono ka nānā nui ʻana no ka maʻi Alzheimer mua i ka poʻe ʻelemakule."
No laila, inā he mea nui ka hana mua ʻana, no ke aha ʻaʻole mākou e loaʻa nā papahana nānā maʻamau no ka maʻi Alzheimer mua? Aia ka pilikia i nā ʻano hana diagnostic a nā kauka e hoʻohana nei i kēia manawa. ʻO kēia mau mea ka positron emission tomography o ka lolo, he pipiʻi a hōʻike i nā mea maʻi i ka radiation. Aia pū kekahi mau hoʻāʻo biomarker e hiki ke ʻike iā Alzheimer, akā koi lākou i nā huki koko invasive a i ʻole nā ​​​​​​punctures lumbar e loaʻa ai ka wai cerebrospinal, kahi mea a nā mea maʻi e hoʻopaneʻe nei.
Eia nō naʻe, ʻaʻole komo hewa nā hoʻāʻo mimi a he kūpono hoʻi, e kūpono ana no ka nānā nui ʻana. ʻOiai ua ʻike mua nā kānaka noiʻi i nā biomarkers mimi no ka maʻi Alzheimer, ʻaʻohe mea kūpono no ka ʻike ʻana i nā pae mua o ka maʻi, ʻo ia hoʻi, ʻaʻohe puka makani gula no ka mālama mua ʻana.
Ua aʻo mua nā kānaka noiʻi ma hope o ke aʻo hou i kahi hui organik i kapa ʻia ʻo formaldehyde ma ke ʻano he biomarker mimi no ka maʻi Alzheimer. Eia nō naʻe, aia kahi no ka hoʻomaikaʻi ʻana i ka ʻike mua ʻana i ka maʻi. Ma kēia haʻawina hou loa, ua kālele lākou i ka formate, kahi metabolite formaldehyde, e ʻike inā hana maikaʻi ia ma ke ʻano he biomarker.
He 574 mau kānaka i komo i ke aʻo ʻana, a ʻo nā mea komo he mau mea manawaleʻa olakino maʻamau a olakino paha a i ʻole he mau kekelē like ʻole o ka holomua o ka maʻi, mai ka emi ʻana o ka noʻonoʻo pilikino a hiki i ka maʻi piha. Ua kālailai nā mea noiʻi i nā laʻana mimi a me ke koko mai nā mea komo a ua hana i kahi loiloi noʻonoʻo.
Ua ʻike ʻia ma ke aʻo ʻana ua kiʻekiʻe nui nā pae waikawa formic urinary i nā hui maʻi Alzheimer āpau a ua pili pū me ka emi ʻana o ka noʻonoʻo i hoʻohālikelike ʻia me nā kaohi olakino, me ka hui emi ʻana o ka noʻonoʻo mua. Hōʻike kēia e hiki i ka waikawa formic ke lawelawe ma ke ʻano he biomarker koʻikoʻi no nā pae mua o ka maʻi Alzheimer.
ʻO ka mea hoihoi, i ka wā i kālailai ai nā kānaka noiʻi i nā pae formate o ka mimi i hui pū ʻia me nā biomarkers koko o Alzheimer, ua ʻike lākou hiki iā lākou ke wānana pololei i ke kahua o ka maʻi e hele nei ka mea maʻi. Eia nō naʻe, pono ka noiʻi hou aku e hoʻomaopopo i ka pilina ma waena o ka maʻi Alzheimer a me ka waikawa formic.
"Ua hōʻike ka waikawa formic mimi i ka ʻike maikaʻi loa no ka nānā mua ʻana no ka maʻi Alzheimer," wahi a nā mea kākau. "He kūpono a he kūpono hoʻi ke kumukūʻai o ka hoʻāʻo ʻana i ka biomarker mimi no ka maʻi Alzheimer a pono e hoʻokomo ʻia i nā nānā olakino maʻamau no ka poʻe ʻelemakule."
Wang, Y. et al. (2022) Loiloi ʻōnaehana o ka waikawa formic urinary ma ke ʻano he biomarker hou no ka maʻi Alzheimer. Nā palena i ka neurobiology o ka ʻelemakule. doi.org/10.3389/fnagi.2022.1046066.
Nā lepili: ka ʻelemakule, ka maʻi Alzheimer, nā biomarkers, ke koko, ka lolo, ka maʻi mau, nā maʻi maʻi, nā hui, ka dementia, nā diagnostics, nā kauka, formaldehyde, neurology, positron emission tomography, noiʻi, tomography, urinalysis
Ma Pittcon 2023 ma Philadelphia, Pennsylvania, ua ninaninau mākou iā Polofesa Joseph Wang, ka mea lanakila o ka Ralph N. Adams Prize ma Analytical Chemistry o kēia makahiki, e pili ana i ka versatility o ka ʻenehana biosensor.
Ma kēia hālāwai ninaninau, kūkākūkā mākou i ka biopsy hanu a pehea e hiki ai ke lilo i mea hana pono e aʻo i nā biomarkers no ka ʻike mua ʻana i nā maʻi me Mariana Leal, Luna Hoʻokele Hui ma Owlstone Medical.
Ma ke ʻano he ʻāpana o kā mākou loiloi SLAS US 2023, ke kūkākūkā nei mākou i ka lab o ka wā e hiki mai ana a me ke ʻano o ia mea me Luigi Da Via, ke Alakaʻi o ka Pūʻulu Hoʻomohala Hoʻāʻo GSK.
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